Hemodialysis is an effective treatment method to improve the survival rate and quality of life of patients with acute and chronic renal failure. Hemodialysis patients often have low immunity and are at high risk of hospital infection. Improving the disinfection effect of the surface of objects in the hemodialysis room is critical to reducing the occurrence of exogenous hospital infection, improving the quality of hemodialysis, and ensuring patient safety. At present, most medical institutions use organic chlorine disinfectants to disinfect the surface of objects in the hemodialysis room. Organic chlorine-containing disinfectants mainly include sodium dichloroisocyanurate, dichloroisocyanuric acid, and trichloroisocyanuric acid. However, organic chlorine-containing disinfectants are volatile, easy to decompose, have residues, and are corrosive . They are highly irritating to the respiratory tract and skin mucosa, the configuration operation is cumbersome, and the disinfection effect is unstable.
The study on the disinfection effect of slightly acidic hypochlorous acid water (SAHW) on the surface of objects in the hemodialysis room showed that it has a disinfection effect equivalent to that of trichloroisocyanuric acid with an effective chlorine concentration of 500 mg/L. Specifically, the study by Tian Jia et al. showed that after SAHW was used to wipe and disinfect the surfaces of objects such as the dialyzer screen, dialyzer knobs, and bed rails of the hemodialysis unit, the qualified rates of disinfection were 100%, 96.67%, and 100%, respectively, while the qualified rates of the trichloroisocyanuric acid group were 90%, 80%, and 90%, respectively, and there was no statistically significant difference between the two (P>0.05).
SAHW has a highly effective killing effect on multi-drug resistant bacteria (such as methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococci, carbapenem-resistant Enterobacteriaceae, pan-resistant Pseudomonas aeruginosa, etc.), with a killing rate of 100%. This shows that SAHW is not only comparable to traditional chlorine-containing disinfectants in terms of disinfection effect, but also performs well in combating multi-drug resistant bacteria.
Slightly acidic hypochlorous acid water has demonstrated good disinfection effects and high efficiency in killing multi-drug resistant bacteria in the disinfection of object surfaces in hemodialysis rooms. It is a safe, reliable and effective disinfectant option.
The disinfection effect of two disinfectants on the surface of objects is shown in Table 1. The disinfection effect of trichloroisocyanuric acid and SAHW with an effective chlorine concentration of 500 mg/L on the surface of objects is shown in Table 2.
There was no significant difference in the qualified rate of the surface of the object after 4 hours (all > 0.05 ). See Table 1 .
SAHW on multi-drug resistant bacteria on the surface of medical record folders showed that the killing rate of hypochlorous acid water on the four multi-drug resistant bacteria MRSA, VRE, CRE, and PDR PA was 100%. See Table 2.
Maintenance hemodialysis is one of the important means for uremia patients to survive. In recent years, the number of patients undergoing maintenance hemodialysis has increased sharply, and the scale of hemodialysis rooms in medical institutions across the country has continued to expand. There have been several cases of hepatitis C and hepatitis B hospital infections caused by hemodialysis in China. At the same time, the incidence of multidrug-resistant bacteria in catheter-related bloodstream infections in maintenance hemodialysis patients has increased year by year, which has a serious impact on the treatment effect and economic burden of patients. Proper disinfection of the surface of objects in the hemodialysis room is of great significance to reducing the incidence of hospital infections .
Inorganic or organic chlorine-containing disinfectants are often used to disinfect the surfaces of objects in the hemodialysis rooms of various medical institutions, such as sodium dichloroisocyanurate , dichloroisocyanuric acid, trichloroisocyanuric acid, sodium hypochlorite ( 84 disinfectant), etc. Chlorine-containing disinfectants are highly effective disinfectants, and trichloroisocyanuric acid is used in the surface disinfection of objects to combat severe acute respiratory syndrome ( SARS ). However, in the daily surface disinfection of objects in the hemodialysis room, chlorine-containing disinfectants have the disadvantages of being volatile, concentration-dependent, highly irritating to the skin and mucous membranes, inconvenient to prepare, and highly corrosive, resulting in unsatisfactory disinfection effects.
BLUEWAV electrolyzed water is an acidic electrolyzed water and alkaline electrolyzed water with special functions obtained by electrolyzing salt or dilute hydrochloric acid using patented technology . The pH value and effective chlorine concentration of hypochlorous acid water can be adjusted according to different requirements of strong acidity and slightly acidity . The main active ingredient is hypochlorous acid ( HCLO/HOCL ), pH3-7 is adjustable , and when the effective chlorine concentration is 10-30mg/L , it has strong bactericidal ability, wide range, no pollution, no effective chlorine residue, no sodium ion residue, no corrosion, safe and reliable, not easy to volatilize, easy to store, harmless to the human body, no irritation to mucous membranes and skin, easy to prepare, low cost, etc.
And the research found that hypochlorous acid water is completely superior to acidic oxidizing potential water. At present, slightly acidic hypochlorous acid water is widely used in agronomy, forestry, animal husbandry, veterinary science, aquaculture and other fields. The Food Safety Committee of Japan has approved hypochlorous acid water as a food additive. Slightly acidic hypochlorous acid water will have a very broad application prospect in the medical field, especially in sanitation and disinfection and hospital infection control.
